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Michael L. Love: proclus molecules blog
Michael L. Love: more parsley info, anti-diarrhea and other matters
Diarrhea is a frequently problem for those who undertake supplementation and vegetarian-style regimens. On the other hand, what for some of us is a minor inconvenience or annoyance can become life-threatening in some parts of the world where there are complicating issues. It is a real problem, which is larger than some of us think, and the dehydration resulting from diarrhea may be dangerous for those who are using supplements as well. First advice is drink plenty of water if you are using supplements. It should be noted that water shock can be fatal in severe cases.

As it happens, certain flavonoids have been documented to have a paradoxical anti-diarrhea property when taken in large doses. This is due to inhibition of the ATP-cAMP-dependent chloride channel (CFTR), and these flavonoids have been suggested as a remedy in cases where diarrhea might become dangerous. Parsley flavonoid shares in the ability to block this channel and slow digestion, so that water can be absorbed from the intestine.

Fortunately, parsley is a widely available commodity, even in some of the poorest of countries. I am recommending that an anti-diarrhea emulsion could include enough parsley to help save lives. It has been demonstrated that such inexpensive preparations can do great good. It can be flavored with a little sweetener for small children. Diarrhea can take its toll, particularly on the young, hopefully this information will help to prevent the death of some little ones.

Interestingly, the cystic fibrosis disease results from a defect in this same chloride channel. The wide range of symptoms indicate how widespread this channel is in the body, including the nasal passages and lungs. Those suffering from intestinal maladies, such as cryptitis, should consider avoiding such things as quercetin and parsley flakes. There is some evidence that we can find alternative flavonoid regimens for them, which do not inhibit the channel. I am including below a salient reference.

Regards,
proclus
http://www.gnu-darwin.org/

Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia


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    Published Monday, January 18, 2010 08:36 PM by proclus
    Filed Under: General Health and Wellness, Weight Loss, Specific Health Concern
    Comments
    proclus said:
    On parsley as diarrheal medicine, there have been some reports of infection from eating raw parsley, so that it is recommended to cook the parsley, if possible, for diarrhea. Additionally, cooking will certainly enhance the flavor, and it will likely improve the quality of the emulsion and the effectiveness of the medicine as well. Even a simple boil in a pot will do.

    Regards,
    proclus
    http://www.gnu-darwin.org/
    January 19, 2010 10:36 AM EST
    proclus said:
    Here are some more references related to flavonoids in general, this story, and apigenin. Of particular note is that curcumin and resveratrol are able to act in the non-paradoxical mode to correct the defect in the cystic fibrosis chloride channel. I haven't had a chance to check the concentrations yet, so it is not clear to me whether they can act paradoxically as well, like apigenin.

    Curcumin, An Atoxic Antioxidant and Natural NF{kappa}B, Cyclooxygenase-2,
    Lipooxygenase, and Inducible Nitric Oxide Synthase Inhibitor: A Shield Against Acute and
    Chronic Diseases
    S. Bengmark
    JPEN J Parenter Enteral Nutr, January 1, 2006; 30 (1): 45-51.

    Cocoa-Related Flavonoids Inhibit CFTR-Mediated Chloride Transport across T84 Human
    Colon Epithelia
    M. Schuier, H. Sies, B. Illek and H. Fischer
    J. Nutr., October 1, 2005; 135 (10): 2320-2325.

    The Chemopreventive Agent Resveratrol Stimulates Cyclic AMP-Dependent Chloride
    Secretion In vitro
    I. Blumenstein, B. Keseru, F. Wolter and J. Stein
    Clin. Cancer Res., August 1, 2005; 11 (15): 5651-5656.

    Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects
    M. E. Egan, M. Pearson, S. A. Weiner, V. Rajendran, D. Rubin, J. Glockner-Pagel, S. Canny, K.
    Du, G. L. Lukacs and M. J. Caplan
    Science, April 23, 2004; 304 (5670): 600-602.

    CFTR activation in human bronchial epithelial cells by novel benzoflavone and
    benzimidazolone compounds
    E. Caci, C. Folli, O. Zegarra-Moran, T. Ma, M. F. Springsteel, R. E. Sammelson, M. H. Nantz,
    M. J. Kurth, A. S. Verkman and L. J. V. Galietta
    Am J Physiol Lung Cell Mol Physiol, July 1, 2003; 285 (1): L180-L188.
    January 19, 2010 02:10 PM EST
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