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Michael L. Love: parsley and bone loss
Osteoporosis and osteopenia were a topic of conversation in my
department at Hopkins today, and as I listened to the discussion, it
occurred to me that flavonoids like parsley apigenin might help to
prevent adverse bone loss. It did not take much digging to find
out that this is indeed the case, and there is even evidence that
flavonoids may reverse bone loss. A quick search turned up this
surprising statement from 2004.
Flavonoids are micronutrients widely present in food of plant origin.
They have been attributed pharmacological properties such as anticancer
and prevention of age-related pathologies. It has been recently
hypothesized that flavonoids increase bone mass and prevent
osteoporosis.
Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF?B and AP-1
It also occurred to me that the real problem is not the normal
osteoclast cells, which are required for the repair and day-to-day
maintenance of bone. The problem of bone loss more likely results
from abnormal osteoclast cells, which have
mutated in similar ways as cancer cells. Moreover, these cells
exhibit an important property of cancer cells: they are highly
invasive. It is not difficult to imagine that flavonoid
molecules, like parsley apigenin, would attenuate this undesired and
abnormal invasiveness of osteoclasts gone bad. High dose apigenin has been demonstrated to kill several types
of abnormal cells. Killing abnormal osteoclasts may reverse bone
loss.
Most importantly, the levels of flavonoid that are required to achieve
some of these desirable effects are easily attainable using the
methods described in this blog. In fact, the consumption of
quercetin containing fruits has been demonstrated to reduce bone loss,
and our methods increase the absorption of quercetin. Quercetin
has been shown to have exceptional properties in the fight against bone
loss, and parsley apigenin has been demonstrated to share in many of
these same properties.
Regards,
proclus
http://www.gnu-darwin.org/
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Published Wednesday, February 17, 2010 09:44 PM by proclus
Filed Under:
General Health and Wellness, Specific Health Concern
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