|
|
Michael L. Love: aspirin hiatus
Now that I have been high dosing flavonoids for a few weeks, I think that it may be time for another change. My stomach acid and digestion have apparently returned to what they were before I started, and I definitely still need my proton pump blocker. I have a hypothesis about this, which is difficult to confirm. It is known that NSAID drugs like aspirin reduce chloride conductance of the CFTR channel. This is due to the reduction of prostaglandins, which in turn are not present in sufficient quantity to produce cAMP and activate the channel. Aspirin users may initially have a reduction of stomach acid due to this fact, but it is well known that the stomach may become irritated and even ulcerated in due course. One reason for this lies in the fact that NSAIDS reduce CFTR gene expression, probably due to reduced genetic activation via prostaglandin receptors, known as PPAR's. With the prostaglandin receptors under-stimulated, due to the presence of the NSAID, insufficient CFTR is made by the cell. This leads to the now famous erosion of the mucosal lining of the stomach. This much is known.
Hypothetically, it is likely that high doses of flavonoids, and other polyphenols such as resveratrol, will produce the same effect as the aspirin and other NSAIDS, because of similar inhibition of prostaglandin synthesis. Stimulation of cAMP production or CFTR activation would be insufficient to correct this protracted problem, because there would simply be not enough CFTR for sufficient mucous production to protect the lining of the stomach.
As I have previously noted, my eyes are also still just a little dry, so that I have two different phenomena to cross check the effect of an aspirin hiatus. It may be one of those cases of too much of a good thing, or in other words; the combination of high flavonoids and aspirin, like the anti-histamine, is simply too strong. It should take at least several days for CFTR expression to recover and I hope to have more tears and reduced stomach complaints again in a week or two. Maybe I can get off the Nexium after all. It will likely be no surprise to other users of proton pump blockers, that I have a third metric as well, that queasy acid alkaseltzer headache and nauseous feeling, which I expect to go as well. Thankfully, this problem has also been mild in its manifestation. It is best to take care of these things before they become a serious problem. Wish me luck.
If this hypothesis is true, then it is another case of the marvelous property of polyphenols to double up on their effects. For example, they inhibit COX and reduce COX expression. Likewise, they may block both CFTR channel activity and expression as well. It would be a profound effect and observation, because these type of double effects explain the refractory nature of CR-related regimens. As it has been noted, one continues to have the benefits of the regimen for at least several days after stopping. Cells have switches that are difficult to toggle back to their previous position, as it were, once they have been flipped. In this case, it is a forgiving regimen.
Having said that, it should be noted that aspirin hiatus may be dangerous for people who have been prescribed aspirin by their doctor. As the coxib fiasco has demonstrated, too much of a good thing can be catastrophic, so that people who are vulnerable to these types of problems should exercise caution with flavonoid regimens as well, especially in the high dose range.
Regards,
proclus
http://www.gnu-darwin.org/
|
| The blog |
|
Michael L. Love: parsley and autism
Michael L. Love: aspirin hiatus upshot
Michael L. Love: citrus pudding recipe
Michael L. Love: parsley recipe alert!
Michael L. Love: parsley and bone loss
Michael L. Love: I Love You!
Michael L. Love: parsley and allergies follow-up
Michael L. Love: parsley and allergies
Michael L. Love: parsley and triglycerides
Michael L. Love: Parsley odyssey continues
Michael L. Love: Community blog to rss extraction code
Michael L. Love: winter bicycling
Michael L. Love: more parsley info, anti-diarrhea and other matters
Michael L. Love: Parsley recipe
Michael L. Love: polyphenols and stable free radicals
Michael L. Love: some bio info, blog links, plus some molecules site news
Michael L. Love: USDA Database for the Flavonoid Content
Michael L. Love: recipe; flax oil, tyrosol lignans update
Michael L. Love: Linus Pauling
|
|
Follow Michael L. Love:
on Google Buzz
|
Published Monday, February 22, 2010 04:57 PM by proclus
Filed Under:
General Health and Wellness, Weight Loss, Specific Health Concern
|
|
| No Comments |
| Anonymous comments are disabled. |
| proclus's Blog |
| All of the information provided by Michael L. Love on this site can be freely distributed, as you like. |